abstract：:Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), causing Coronavirus Disease 19 (COVID-19), emerged at the end of 2019 and quickly spread to cause a global pandemic with severe socio-economic consequences. The early sequencing of its RNA genome revealed its high similarity to SARS, likely to have originat...

journal_title：International journal of molecular sciences

authors： Rogstam A,Nyblom M,Christensen S,Sele C,Talibov VO,Lindvall T,Rasmussen AA,André I,Fisher Z,Knecht W,Kozielski F

更新日期：2020-10-06 00:00:00

abstract：:The interactions of plants with environment and insects are bi-directional and dynamic. Consequently, a myriad of mechanisms has evolved to engage organisms in different types of interactions. These interactions can be mediated by allelochemicals known as volatile organic compounds (VOCs) which include volatile terpen...

journal_title：International journal of molecular sciences

authors： Boncan DAT,Tsang SSK,Li C,Lee IHT,Lam HM,Chan TF,Hui JHL

更新日期：2020-10-06 00:00:00

abstract：:Krüppel-like factor 4 (Klf4) plays an important role in the transition from proliferation to differentiation in a wide variety of cells. Previous studies demonstrated its critical role in the luteal transition of preovulatory granulosa cells (GCs). This study used cultured rat preovulatory GCs to investigate the mecha...

journal_title：International journal of molecular sciences

authors： Choi H,Roh J

更新日期：2020-10-06 00:00:00

abstract：:Lattice degeneration involves thinning of the retina that occurs over time. Here we performed an immunohistological study of tissue sections of human peripheral retinal lattice degeneration to investigate if retinal pigment epithelium (RPE) cells are involved in the pathogenesis of this condition. In two cases of reti...

journal_title：International journal of molecular sciences

authors： Mizuno H,Fukumoto M,Sato T,Horie T,Kida T,Oku H,Nakamura K,Jin D,Takai S,Ikeda T

更新日期：2020-10-05 00:00:00

abstract：:Neurons are particularly susceptible to microtubule (MT) defects and deregulation of the MT cytoskeleton is considered to be a common insult during the pathogenesis of neurodegenerative disorders. Evidence that dysfunctions in the MT system have a direct role in neurodegeneration comes from findings that several forms...

journal_title：International journal of molecular sciences

authors： Sferra A,Nicita F,Bertini E

更新日期：2020-10-05 00:00:00

abstract：:Although epidemiological studies have shown a relationship between periodontal disease and pancreatic cancer, the molecular mechanisms involved remain unclear. In this study, the effects of systemic administration of Porphyromonas gingivalis lipopolysaccharide (PG-LPS) on gene expression were comprehensively explored ...

journal_title：International journal of molecular sciences

authors： Hiraki D,Uehara O,Kuramitsu Y,Morikawa T,Harada F,Yoshida K,Akino K,Chiba I,Asaka M,Abiko Y

更新日期：2020-10-05 00:00:00

abstract：:Essential oils (EOs) have attracted considerable interest in the past few years, with increasing evidence of their antibacterial, antiviral, antifungal, and insecticidal effects. However, as they are highly volatile, the administration of EOs to achieve the desired effects is challenging. Therefore, nanotechnology-bas...

journal_title：International journal of molecular sciences

authors： Mihai AD,Chircov C,Grumezescu AM,Holban AM

更新日期：2020-10-05 00:00:00

abstract：:Parkinson's disease (PD) is a complex disorder underpinned by both environmental and genetic factors. The latter only began to be understood around two decades ago, but since then great inroads have rapidly been made into deconvoluting the genetic component of PD. In particular, recent large-scale projects such as gen...

journal_title：International journal of molecular sciences

authors： Hall A,Bandres-Ciga S,Diez-Fairen M,Quinn JP,Billingsley KJ

更新日期：2020-10-04 00:00:00

abstract：:Metastatic spread represents the leading cause of disease-related mortality among cancer patients. Many cancer patients suffer from metastatic relapse years or even decades after radical surgery for the primary tumor. This clinical phenomenon is explained by the early dissemination of cancer cells followed by a long p...

journal_title：International journal of molecular sciences

authors： Korentzelos D,Clark AM,Wells A

更新日期：2020-10-03 00:00:00

abstract：:Dual drug-loaded nanotherapeutics can play an important role against the drug resistance and side effects of the single drugs. Doxorubicin and sorafenib were efficiently co-encapsulated by tailor-made poly([R,S]-3-hydroxybutyrate) (PHB) using an emulsion-solvent evaporation method. Subsequent poly(ethylene glycol) (PE...

journal_title：International journal of molecular sciences

authors： Babos G,Rydz J,Kawalec M,Klim M,Fodor-Kardos A,Trif L,Feczkó T

更新日期：2020-10-03 00:00:00

abstract：:Melanin is an important phenolic skin pigment found throughout the animal kingdom. Tyrosine and its hydroxylated product dopa provide the starting material for melanin biosynthesis in all animals. Through a set of well-established reactions, they are converted to 5,6-dihydroxyindole (DHI) and DHI-2-carboxylic acid (DH...

journal_title：International journal of molecular sciences

authors： Sugumaran M,Evans J,Ito S,Wakamatsu K

更新日期：2020-10-03 00:00:00

abstract：:Speckle-type BTB/POZ protein (SPOP) is a substrate recognition receptor of the cullin-3 (CUL3)/RING type ubiquitin E3 complex. To date, approximately 30 proteins have been identified as ubiquitinated substrates of the CUL3/SPOP complex. Pathologically, missense mutations in the substrate-binding domain of SPOP have be...

journal_title：International journal of molecular sciences

authors： Maekawa M,Higashiyama S

更新日期：2020-10-02 00:00:00

abstract：:Adenosine is a neuromodulator that has been involved in aging and neurodegenerative diseases as Alzheimer's disease (AD). In the present work, we analyzed the possible modulation of purine metabolites, 5'nucleotidase (5'NT) and adenosine deaminase (ADA) activities, and adenosine monophosphate (AMP)-activated protein k...

journal_title：International journal of molecular sciences

authors： Sánchez-Melgar A,Albasanz JL,Pallàs M,Martín M

更新日期：2020-10-02 00:00:00

abstract：:Liquid water is considered to be a peculiar example of glass forming materials because of the possibility of giving rise to amorphous phases with different densities and of the thermodynamic anomalies that characterize its supercooled liquid phase. In the present work, literature data on the density of bulk liquid wat...

journal_title：International journal of molecular sciences

authors： Mallamace F,Mensitieri G,Mallamace D,Salzano de Luna M,Chen SH

更新日期：2020-10-01 00:00:00

abstract：:The carotid body may undergo plasticity changes during development/ageing and in response to environmental (hypoxia and hyperoxia), metabolic, and inflammatory stimuli. The different cell types of the carotid body express a wide series of growth factors and corresponding receptors, which play a role in the modulation ...

journal_title：International journal of molecular sciences

authors： Stocco E,Barbon S,Tortorella C,Macchi V,De Caro R,Porzionato A

更新日期：2020-10-01 00:00:00

abstract：:Ly-6/uPAR or three-finger proteins (TFPs) contain a disulfide-stabilized β-structural core and three protruding loops (fingers). In mammals, TFPs have been found in epithelium and the nervous, endocrine, reproductive, and immune systems. Here, using heteronuclear NMR, we determined the three-dimensional (3D) structure...

journal_title：International journal of molecular sciences

authors： Paramonov AS,Kocharovskaya MV,Tsarev AV,Kulbatskii DS,Loktyushov EV,Shulepko MA,Kirpichnikov MP,Lyukmanova EN,Shenkarev ZO

更新日期：2020-10-01 00:00:00

abstract：:The engineering of T cells through expression of chimeric antigen receptors (CARs) against tumor-associated antigens (TAAs) has shown significant potential for use as an anti-cancer therapeutic. The development of strategies for flexible and modular CAR T systems is accelerating, allowing for multiple antigen targetin...

journal_title：International journal of molecular sciences

authors： Sutherland AR,Owens MN,Geyer CR

更新日期：2020-09-30 00:00:00

abstract：:Recent comparative studies have indicated distinct expression profiles of short, non-coding microRNAs (miRNAs) in various types of cancer, including oral squamous cell carcinoma (OSCC). In this study, we employed a hybrid approach using Drosophila melanogaster as well as OSCC cell lines to validate putative targets of...

journal_title：International journal of molecular sciences

authors： Jung JE,Lee JY,Kim IR,Park SM,Kang JW,Kim YH,Park HR,Lee JH

更新日期：2020-09-30 00:00:00

abstract：:Sleep-wake disorders are highly prevalent disorders, which can lead to negative effects on cognitive, emotional and interpersonal functioning, and can cause maladaptive metabolic changes. Recent studies support the notion that metabolic processes correlate with sleep. The study of metabolite biomarkers (metabolomics) ...

journal_title：International journal of molecular sciences

authors： Humer E,Pieh C,Brandmayr G

更新日期：2020-09-30 00:00:00

abstract：:Sudden sensorineural hearing loss (SSNHL) is a medical emergency, making detailed examination to determine possible causes and early treatment important. However, etiological examinations in SSNHL do not always reveal a cause, and several factors have been found to affect treatment outcomes. Various studies are being ...

journal_title：International journal of molecular sciences

authors： Doo JG,Kim D,Kim Y,Yoo MC,Kim SS,Ryu J,Yeo SG

更新日期：2020-09-30 00:00:00

abstract：:Attributed to the tropism for host microvascular endothelium lining the blood vessels, vascular inflammation and dysfunction represent salient features of rickettsial pathogenesis, yet the details of fundamentally important pathogen interactions with host endothelial cells (ECs) as the primary targets of infection rem...

journal_title：International journal of molecular sciences

authors： Sahni A,Narra HP,Sahni SK

更新日期：2020-09-29 00:00:00

abstract：:Parkinson's disease (PD) is one of the most common neurodegenerative disorders. The neuropathological features of PD are selective and progressive loss of dopaminergic neurons in the substantia nigra pars compacta, deficiencies in striatal dopamine levels, and the presence of intracellular Lewy bodies. Interactions am...

journal_title：International journal of molecular sciences

authors： Wang R,Sun H,Wang G,Ren H

更新日期：2020-09-29 00:00:00

abstract：:Skeletal muscle has a remarkable plasticity, and its phenotype is strongly influenced by hormones, transcription factors, and physical activity. However, whether skeletal phenotype can be oriented or not during early embryonic stages has never been investigated. Here, we report that pyruvate as the only source of carb...

journal_title：International journal of molecular sciences

authors： Bertrand-Gaday C,Letheule M,Blanchet E,Vernus B,Pessemesse L,Bonnet-Garnier A,Bonnieu A,Casas F

更新日期：2020-09-29 00:00:00

abstract：:Water limitation represents the main environmental constraint affecting crop yield worldwide. Photosynthesis is a primary drought target, resulting in over-reduction of the photosynthetic electron transport chain and increased production of reactive oxygen species in plastids. Manipulation of chloroplast electron dist...

journal_title：International journal of molecular sciences

authors： Karlusich JJP,Arce RC,Shahinnia F,Sonnewald S,Sonnewald U,Zurbriggen MD,Hajirezaei MR,Carrillo N

更新日期：2020-09-29 00:00:00

abstract：:Gomisin N (GN) is lignin derived from Schisandra chinensis that has been reported to exhibit hepato-protective, anti-cancer, and anti-inflammatory effects. However, its role in whole-body energetic homeostasis remains unclear. In this study, we employed Drosophila melanogaster as a diet-induced obese model to elucidat...

journal_title：International journal of molecular sciences

authors： Lee JY,Lee JH,Cheon CK

更新日期：2020-09-29 00:00:00

abstract：:Immune modulation is a very modern medical field for targeting viral infections. In the race to develop the best immune modulator against viruses, curcumin, as a natural product, is inexpensive, without side effects, and can stimulate very well certain areas of the human immune system. As a bright yellow component of ...

journal_title：International journal of molecular sciences

authors： Ailioaie LM,Litscher G

更新日期：2020-09-28 00:00:00

abstract：:The presence of abnormal ovarian ratios of myo-inositol (MI) to D-chiro-inositol (DCI) is a recurrent feature in PCOS. Available evidence suggests that MI and DCI may modulate steroid biosynthesis, likely in an opposite manner. Specifically, MI seems to induce estrogen production, while DCI has a role in the synthesis...

journal_title：International journal of molecular sciences

authors： Unfer V,Dinicola S,Laganà AS,Bizzarri M

更新日期：2020-09-28 00:00:00

abstract：:Ketamine, a multimodal anesthetic drug, has become increasingly popular in the treatment of pain following traumatic injury as well as treatment-resistant major depressive disorders. However, the psychological impact of this dissociative medication on the development of stress-related disorders such as post-traumatic ...

journal_title：International journal of molecular sciences

authors： Choi KH,Berman RY,Zhang M,Spencer HF,Radford KD

更新日期：2020-09-28 00:00:00

abstract：:A tight junction (TJ) makes a physical barrier in the epidermal cells of skin. Ultraviolet (UV) light may disrupt the TJ barrier, but the mechanism has not been well clarified. Weak UVB (5 mJ/cm2) caused mislocalization of claudin-1 (CLDN1), a component of the TJ strand, and disruption of TJ barrier in human keratinoc...

journal_title：International journal of molecular sciences

authors： Kobayashi M,Shu S,Marunaka K,Matsunaga T,Ikari A

更新日期：2020-09-27 00:00:00

abstract：:Sugars, which are important signaling molecules, regulate diverse biological processes in plants. However, the convergent regulatory mechanisms governing these physiological activities have not been fully elucidated. MODIFIER OF snc1-1 (MOS1), a modulator of plant immunity, also regulates floral transition, cell cycle...

journal_title：International journal of molecular sciences

authors： Zhang N,Wang M,Huang J,Yang L,Wang Z,Wu D,Shu X

更新日期：2020-09-26 00:00:00

abstract：:For the post-surgical treatment of oral wounds and mucosal defects beyond a certain size, the gold standard is still an autologous skin or mucosal graft in combination with complex suturing techniques. A variety of techniques and biomaterials has been developed for sutureless wound closure including different tissue g...

journal_title：International journal of molecular sciences

authors： Birkelbach MA,Smeets R,Fiedler I,Kluwe L,Wehner M,Trebst T,Hartjen P

更新日期：2020-09-26 00:00:00

abstract：:This study aimed to determine the effect of selected essential oil compounds (EOCs) on the antibacterial activity of β-lactam antibiotics (βLAs) against methicillin-resistant Staphylococcus aureus (MRSA) strains. The following parameters were studied: antibiotic susceptibility testing, detection of mecA gene and evalu...

journal_title：International journal of molecular sciences

authors： Kwiatkowski P,Łopusiewicz Ł,Pruss A,Kostek M,Sienkiewicz M,Bonikowski R,Wojciechowska-Koszko I,Dołęgowska B

更新日期：2020-09-26 00:00:00

abstract：:Arrhythmias in Brugada syndrome patients originate in the right ventricular outflow tract (RVOT). Over the past few decades, the characterization of the unique anatomy and electrophysiology of the RVOT has revealed the arrhythmogenic nature of this region. However, the mechanisms that drive arrhythmias in Brugada synd...

journal_title：International journal of molecular sciences

authors： Blok M,Boukens BJ

更新日期：2020-09-25 00:00:00

abstract：:The exposure of living organisms to environmental stress triggers defensive responses resulting in the activation of protective processes. Whenever the exposure occurs at low doses, defensive effects overwhelm the adverse effects of the exposure; this adaptive situation is referred to as "hormesis". Environmental, phy...

journal_title：International journal of molecular sciences

authors： Rossnerova A,Izzotti A,Pulliero A,Bast A,Rattan SIS,Rossner P

更新日期：2020-09-25 00:00:00

abstract：:Riboflavin is the biological precursor of two important flavin cofactors-flavin adenine dinucleotide (FAD) and flavin mononucleotide (FMN)-that are critical prosthetic groups in several redox enzymes. While dietary supplementation with riboflavin is a recognized support therapy in several inborn errors of metabolism, ...

journal_title：International journal of molecular sciences

authors： Ribeiro JV,Gomes CM,Henriques BJ

更新日期：2020-09-25 00:00:00

abstract：:Lichens, composite organisms resulting from the symbiotic association between the fungi and algae, produce a variety of secondary metabolites that exhibit pharmacological activities. This study aimed to investigate the anti-inflammatory activities of the secondary metabolite atraric acid produced by Heterodermia hypol...

journal_title：International journal of molecular sciences

authors： Mun SK,Kang KY,Jang HY,Hwang YH,Hong SG,Kim SJ,Cho HW,Chang DJ,Hur JS,Yee ST

更新日期：2020-09-25 00:00:00

abstract：:In the present study, we investigated the signal transduction of mutants of the eel follicle-stimulating hormone receptor (eelFSHR). Specifically, we examined the constitutively activating mutant D540G in the third intracellular loop, and four inactivating mutants (A193V, N195I, R546C, and A548V). To directly assess f...

journal_title：International journal of molecular sciences

authors： Byambaragchaa M,Kim JS,Park HK,Kim DJ,Hong SM,Kang MH,Min KS

更新日期：2020-09-25 00:00:00

abstract：:Cannabidiol (CBD) is known for its vasorelaxant (including in the human pulmonary artery), anti-proliferative and anti-inflammatory properties. The aim of our study was to examine the potential preventive effect of chronic CBD administration (10 mg/kg/day for three weeks) on monocrotaline (MCT)-induced pulmonary hyper...

journal_title：International journal of molecular sciences

authors： Sadowska O,Baranowska-Kuczko M,Gromotowicz-Popławska A,Biernacki M,Kicman A,Malinowska B,Kasacka I,Krzyżewska A,Kozłowska H

更新日期：2020-09-25 00:00:00

abstract：:Intracerebral hemorrhage (ICH) is a major cause of stroke, with high mortality and morbidity. There is no effective pharmacological therapy for ICH. Previous studies have indicated that CXCR4 antagonists reduced microglia activation, attenuated infiltration of T cells, and improved functional recovery in ischemic stro...

journal_title：International journal of molecular sciences

authors： Yu SJ,Wu KJ,Wang YS,Song JS,Wu CH,Jan JJ,Bae E,Chen H,Shia KS,Wang Y

更新日期：2020-09-25 00:00:00

abstract：:Clozapine (CLZ) is an approved antipsychotic agent for the medication of treatment-resistant schizophrenia but is also well known as one of the most toxic antipsychotics. Recently, the World Health Organization's (WHO) global database (VigiBase) reported the relative lethality of severe adverse reactions of CLZ. Agran...

journal_title：International journal of molecular sciences

authors： Okada M,Fukuyama K,Shiroyama T,Murata M

更新日期：2020-09-24 00:00:00